39 research outputs found
Cinema into the Real.
Cinema into the Real is the practice of creating an affect based encounter between film and the lived world where their thresholds shift. It is an inquiry into the possibility for navigating what Gilles Deleuze calls the 'not-yet-thoughf brought into existence by an irrational form of cinema comprised of crystalline time-images. How does the schema of normative cinema fiction and documentary stand in for the lived world, and how might the statements, maps and spaces of this cinema be made fluid to form a more radical moving image, one that is further implicated in, and may open up insightful gaps for, our experience There are three facets to this inquiry: first, the emergent and imaginative situation of filmmaking itself, where the very intention to make moving images produces a new frame through which to practise everyday life, a cinema of action and alteration secondly, the invention of my conceptual persona as filmmaker, an uncommon self that I have cultivated in order to approach filmmaking as in part alien to its methods of production thirdly, the exploration of a limit in thought (which is the state of affect, commonly experienced as panic) by way of a mental gap brought into being by aberrant moving images. Twelve films (and cinema interventions) were made, and these are thinking spaces in themselves. Between the theoretical text written, and the films produced, I have extended the flight line projected in Deleuze's two cinema books, in an attempt to do film as an art practice of experimental philosophy, and to navigate a space between cinema and the lived world. This minor cinema of which I speak, and which I practise, is acquired by destratification and drifting, courts affect, and can, I will argue, enable new aspects of (non-habitual) thought
Peer review and the publication process
Aims:
To provide an overview of the peer review process, its various types, selection of peer reviewers, the purpose and significance of the peer review with regard to the assessment and management of quality of publications in academic journals.
Design:
Discussion paper.
Methods:
This paper draws on information gained from literature on the peer review process and the authors' knowledge and experience of contributing as peer reviewers and editors in the field of health care, including nursing.
Results:
There are various types of peer review: single blind; double blind; open; and post-publication review. The role of the reviewers in reviewing manuscripts and their contribution to the scientific and academic community remains important
Knowledge-based energy functions for computational studies of proteins
This chapter discusses theoretical framework and methods for developing
knowledge-based potential functions essential for protein structure prediction,
protein-protein interaction, and protein sequence design. We discuss in some
details about the Miyazawa-Jernigan contact statistical potential,
distance-dependent statistical potentials, as well as geometric statistical
potentials. We also describe a geometric model for developing both linear and
non-linear potential functions by optimization. Applications of knowledge-based
potential functions in protein-decoy discrimination, in protein-protein
interactions, and in protein design are then described. Several issues of
knowledge-based potential functions are finally discussed.Comment: 57 pages, 6 figures. To be published in a book by Springe
The Scientific Foundations of Forecasting Magnetospheric Space Weather
The magnetosphere is the lens through which solar space weather phenomena are focused and directed towards the Earth. In particular, the non-linear interaction of the solar wind with the Earth's magnetic field leads to the formation of highly inhomogenous electrical currents in the ionosphere which can ultimately result in damage to and problems with the operation of power distribution networks. Since electric power is the fundamental cornerstone of modern life, the interruption of power is the primary pathway by which space weather has impact on human activity and technology. Consequently, in the context of space weather, it is the ability to predict geomagnetic activity that is of key importance. This is usually stated in terms of geomagnetic storms, but we argue that in fact it is the substorm phenomenon which contains the crucial physics, and therefore prediction of substorm occurrence, severity and duration, either within the context of a longer-lasting geomagnetic storm, but potentially also as an isolated event, is of critical importance. Here we review the physics of the magnetosphere in the frame of space weather forecasting, focusing on recent results, current understanding, and an assessment of probable future developments.Peer reviewe
Gravity, Twistors and the MHV Formalism
We give a self-contained derivation of the MHV amplitudes for gravity and use
the associated twistor generating function to define a twistor action for the
MHV diagram approach to gravity. Starting from a background field calculation
on a spacetime with anti self-dual curvature, we obtain a simple spacetime
formula for the scattering of a single, positive helicity linearized graviton
into one of negative helicity. Re-expressing our integral in terms of twistor
data allows us to consider a spacetime that is asymptotic to a superposition of
plane waves. Expanding these out perturbatively yields the gravitational MHV
amplitudes of Berends, Giele & Kuijf. We go on to take the twistor generating
function off-shell at the perturbative level. Combining this with a twistor
action for the anti self-dual background, we obtain a twistor action for the
MHV diagram approach to perturbative gravity. We finish by extending these
results to supergravity, in particular N=4 and N=8.Comment: 39 pages, 3 figures. Minor typos corrected, some clarification adde
Obstructive sleep apnea is associated with depressive symptoms in pregnancy
Study Objectives
In pregnancy, the prevalence of both obstructive sleep apnea (OSA) and depression increases. Research reveals an association in the general population with up to 45% of patients diagnosed with OSA having depressive symptoms. Therefore, this study aimed to investigate the relationship between OSA and depression in pregnant women.
Methods
One hundred and eighty-nine women ≥26 weeks pregnant were recruited from a tertiary perinatal hospital. This cross-sectional study measured OSA (Apnea Hypopnea Index, AHI, using an ApneaLink device) and symptoms of depression (Edinburgh Postnatal Depression Scale, EPDS). Data were collected from medical records including participant age, ethnicity, parity, BMI, smoking status, history of depression, and use of antidepressants.
Results
Of the consenting women, data from 124 were suitable for analysis. Twenty women (16.1%) had OSA (AHI ≥ 5 events/h) and 11 (8.8%) had depressive symptoms (EPDS > 12). Women with OSA were more likely to have depressive symptoms after adjusting for covariates, odds ratio = 8.36, 95% CI [1.57, 44.46]. OSA was also related to higher EPDS scores and these were greater in women with a history of depression.
Conclusions
During late pregnancy women with OSA had eight times the odds of having depressive symptoms. Furthermore, an interaction was found between OSA and history of depression. Specifically, in women with no history of depression, OSA increases depressive symptoms. In women with a history of depression, OSA has an even stronger effect on depressive symptomology. This suggests screening for OSA in pregnancy may identify women prone to future depressive episodes and allow for targeted interventions
Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks
A major challenge in drug discovery is to distinguish the molecular targets of a bioactive compound from the hundreds to thousands of additional gene products that respond indirectly to changes in the activity of the targets. Here, we present an integrated computational-experimental approach for computing the likelihood that gene products and associated pathways are targets of a compound. This is achieved by filtering the mRNA expression profile of compound-exposed cells using a reverse-engineered model of the cell's gene regulatory network. We apply the method to a set of 515 whole-genome yeast expression profiles resulting from a variety of treatments (compounds, knockouts and induced expression), and correctly enrich for the known targets and associated pathways in the majority of compounds examined. We demonstrate our approach with PTSB, a growth inhibitory compound with a previously unknown mode of action, by predicting and validating thioredoxin and thioredoxin reductase as its target